Pancreatic encephalopathy, a little known complication of acute pancreatitis.

A 62-year-old male presented with severe post-endoscopic retrograde cholangiopancreatography (post-ERCP) acute pancreatitis. He required admission to the Intensive Care Unit (ICU) twice due to respiratory and renal failure and neurological deterioration. On the hospitalization ward, he presented a fluctuating alteration of the level of consciousness, with bradypsychia, disorientation and somnolence, which persisted after hemodynamic, metabolic and renal stabilization. A brain magnetic resonance imaging (MRI) was performed showing focal lesions due to small vessel disease, some with cavitations due to necrosis, and mild to moderate subcortical atrophy. A diagnosis of pancreatic encephalopathy was made given the clinical and radiological findings. The patient recovered full cognitive capacity after one week with adequate nutrition supported by protein supplementation.

Biopsia hepática percutánea bajo sedación con propofol. Modelo de procedimiento seguro y eficaz / No disponible

INTRODUCCIÓN: la biopsia hepática percutánea es un procedimiento necesario para el diagnóstico de hepatopatías no exento de complicaciones y con malestar psicológico para el paciente. OBJETIVO: determinar el perfil de seguridad del propofol en la biopsia hepática percutánea, las complicaciones de la técnica per se y la satisfacción de los pacientes tras su realización. MÉTODOS: estudio observacional retrospectivo mediante recogida de datos de tolerancia y complicaciones en pacientes sometidos a biopsia hepática bajo sedación profunda con propofol. Valoración de la calidad y satisfacción percibida por los pacientes mediante una encuesta transversal. RESULTADOS: incluimos 97 pacientes con una dosis media de propofol de 170,46 mg. De las complicaciones derivadas de la sedación, se registraron seis desaturaciones leves (6,2 %) resueltas con maniobras posturales (50 %) y parada de la bomba de propofol (50 %) y once episodios de hipotensión (11,3 %) resueltos de forma espontánea (82,82 %) o fluidoterapia (18,18 %). De las complicaciones derivadas de la técnica, se registraron tres casos de dolor precoz (3,1 %) y uno tardío (1,03 %), todos resueltos con 1 g de paracetamol intravenoso. Todos los pacientes iniciaron tolerancia oral y fueron dados de alta a las 24 horas del procedimiento sin necesidad de analgesia ambulatoria. La satisfacción general, así como el malestar psicológico fueron evaluados como muy buenos/excelentes en el 100 % de los pacientes. DISCUSIÓN: el propofol presenta un adecuado perfil de seguridad en la biopsia hepática y mantiene el éxito de la prueba, con buena tolerancia de la misma por el paciente. Consideramos posible ampliar la utilidad de la sedación con propofol a este procedimiento

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Severe COVID-19 after liver transplantation, surviving the pitfalls of learning on-the-go: Three case reports.

BACKGROUND: The novel coronavirus 2019 (COVID-19) pandemic has dramatically transformed the care of the liver transplant patient. In patients who are immunosuppressed and with multiple comorbidities, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been associated with increased severity and mortality. The main objective of this report is to communicate our experience in the therapeutic management of SARS-CoV-2 infection in 3 liver transplant patients. Secondly, we stress the management and investigation of the contagious spreading into a liver transplant ward. CASE SUMMARY: The patients were two women (aged 61 years and 62 years) and one man (aged 68 years), all of them having recently received a liver transplant. All three patients required intensive care unit admission and invasive mechanical ventilation. Two of them progressed severely until death. The other one, who received tocilizumab, had a good recovery. In the outbreak, the wife of one of the patients and four healthcare professionals involved in their care were also infected. CONCLUSION: We illustrate in detail the evolution of a nosocomial COVID-19 outbreak in a liver transplant ward. We believe that these findings will contribute to a better understanding of the natural history of the disease and will improve the treatment of the liver transplant patient with COVID-19.

Percutaneous hepatic biopsy under propofol sedation. A safe and effective procedure.

INTRODUCTION: the percutaneous hepatic biopsy is a necessary procedure for the diagnosis of liver diseases which can cause complications and psychological discomfort for the patient. AIMS: to determine the safety profile of propofol in percutaneous hepatic biopsy, the complications of the technique per se and patients satisfaction once completed. METHODS: a retrospective observational study was performed via the acquisition of data of tolerance and perceived quality by the patients using a transversal survey. RESULTS: ninety-seven patients were included with an average propofol dose of 170.46 mg. Of the complications resulting from the sedation, there were six slight desaturations (6.2 %) resolved with a forehead maneuver (50 %) or cessation of the propofol infusion pump (50 %) and eleven hypotension episodes (11.3 %) resolved without intervention (82.82 %) or with fluid replacement (18.18 %). Of the complications resulting from the technique, there were three cases of early-onset pain (3.1 %) and one delayed (1.03 %); all were resolved with 1 g of intravenous paracetamol. All patients were discharged with oral tolerance and without the need for analgesia 24 hours after the procedure. General satisfaction, as well as psychological discomfort, were evaluated as "very good/excellent" in 100 % of the patients. DISCUSSION: propofol demonstrated a favorable safety profile in hepatic biopsy, aiding in the ultimate success of the procedure and tolerance for the patient. We propose the expansion of the use of sedation with propofol to this procedure.

Úlceras de Cameron: dos formas de presentación clínica de una hemorragia digestiva alta infrecuente / Cameron ulcers: two clinical presentations of an unusual upper gastrointestinal hemorrhage

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